Update on the Roles of Rice MAPK Cascades

The mitogen-activated protein kinase (MAPK) cascades have been validated playing critical roles in diverse aspects of plant biology, from growth and developmental regulation, biotic and abiotic stress responses, to phytohormone signal transduction or responses. A classical MAPK cascade consists of a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK), and a MAPK. From the 75 MAPKKKs, eight MAPKKs, and 15 MAPKs of rice, a number of them have been functionally deciphered. Here, we update recent advances in knowledge of the roles of rice MAPK cascades, including their components and complicated action modes, their diversified functions controlling rice growth and developmental responses, coordinating resistance to biotic and abiotic stress, and conducting phytohormone signal transduction. Moreover, we summarize several complete MAPK cascades that harbor OsMAPKKK-OsMAPKK-OsMAPK, their interaction with different upstream components and their phosphorylation of diverse downstream substrates to fulfill their multiple roles. Furthermore, we state a comparison of networks of rice MAPK cascades from signal transduction crosstalk to the precise selection of downstream substrates. Additionally, we discuss putative concerns for elucidating the underlying molecular mechanisms and molecular functions of rice MAPK cascades in the future.     

Three distinct optical-switching states in phase-change materials containing impurities:From physical origin to material design

Ge2Sb2Tes is the most widely utilized chalcogenide phase-change material for non-volatile photonic applications,which undergoes amorphous-cubic and cubic-hexagonal phase transition under external excitations.However,the cubic-hexagonal optical contrast is negligible,only the amorphous-cubic phase transition of Ge2Sb2Te5 is available.This limits the optical switching states of traditional active dis-plays and absorbers to two.We find that increasing structural disorder difference of cubic-hexagonal can increase optical contrast close to the level of amorphous-cubic.Therefore,an amorphous-cubic-hexagonal phase transition with high optical contrast is realized.Using this phase transition,we have developed display and absorber with three distinct switching states,improving the switching perfor-mance by 50％.Through the combination of first-principle calculations and experiments,we reveal that the key to increasing structural disorder difference of amorphous,cubic and hexagonal phases is to intro-duce small interstitial impurities(like N)in Ge2Sb2Tes,rather than large substitutional impurities(like Ag)previously thought.This is explained by the formation energy and lattice distortion.Based on the impurity atomic radius,interstitial site radius and formation energy,C and B are also potential suit-able impurities.In addition,introducing interstitial impurities into phase-change materials with van der Waals gaps in stable phase such as GeSb4Te7,GeSb2Te4,Ge3Sb2Te6,Sb2Te3 will produce high optical con-trast amorphous-metastable-stable phase transition.This research not only reveals the important role of interstitial impurities in increasing the optical contrast between metastable-stable phases,but also proposes varieties of candidate matrices and impurities.This provides new phase-change materials and design methods for non-volatile optical devices with multi-switching states.     

基于WebGL的3D立库可视化系统设计与实现

针对当前扩大化和普及化的仓储物流,提出了一种3D自动化立体仓库可视化系统的实现方案,用以解决仓储系统中遇到的数据不直观的问题。该系统采用JavaScript编程语言,以Three.js引擎为基础,构建了基于WebGL的三维自动化立体仓库的可视化系统,该系统能有效直观的进行仓储管理,适合现代化仓储企业的管理需求。     

论三峡水库“蓄清排浑”运用方式及其优化

泥沙问题是三峡工程的关键技术问题之一,在三峡工程论证和初步设计阶段提出水库采取"蓄清排浑"的运用方式,可以解决泥沙问题。2003年水库蓄水运用以来的实践表明,水库基本遵循了"蓄清排浑"调度运用原则,并根据上游来水来沙减少等新情况对水库运用方式进行了优化调整。本文系统分析了三峡水库"蓄清排浑"运行方式及其优化调整的利弊,包括提前5年实施175 m试验性蓄水、汛期水位动态变化、汛末提前蓄水等对水库淤积和坝下游河道演变的影响,提出了进一步优化水库调度方式,形成"蓄清排浑"运用的新模式,保持水库长期使用的建议,试图为三峡水库科学高效安全运用提供科技支撑。     

新时代长江鱼类多样性保护的思考

长江是我国第一大河流,是世界生物多样性的热点区域,也是我国鱼类多样性最高的河流之一。在介绍长江鱼类主要生态习性生境条件的基础上,分析了导致鱼类多样性下降的主要因素——生境丧失和过度捕捞,并简要总结了目前已采取的保护措施及存在的问题,提出了关于新时期长江鱼类多样性保护的思考与建议:①建立以流域管理机构牵头,相关部门和地方共同组建流域生态保护机制;②有计划开展支流及通江湖泊的生态恢复,使支流的小水电逐步退出,使原本的通江湖泊恢复自然江湖关系;③提高民众环保意识,积极建立全流域禁捕机制和休闲垂钓机制,并让垂钓者成为渔政的管理者和监督者。     

三软煤层综采工作面防治煤层自然发火技术研究

针对超化煤矿22011A三软煤层工作面在采掘接替计划安排中需长期停产存在煤层自然发火隐患的问题，提出了多种防治煤层自然发火技术方案，并从每种方案的经济性、安全性、操作性等方面进行论证、比较，择优采取工作面正常通风情况下的防治煤层自然发火的技术方案，确保综采工作面停采期间的安全性，取得了显著的经济效益，对三软煤层自然发火防治工作具有重要的指导意义。     

淮河入江水道行洪能力分析

入江水道是淮河下游最大的泄洪河道,承担着淮河上中游70%以上的洪水泄入长江。根据1961—2018年大洪水期间的实测资料,利用水位流量法计算分析入江水道的泄洪能力和防洪能力。结果表明:因历史客观条件限制以及4个梯级控制河段整治的难度与复杂性,在不同时期各控制河段的行洪能力呈现各自不同的特点;经过多年持续有效治理,河道行洪能力整体得到提高;由近年来实测资料推算,各控制河段的行洪能力基本达到设计要求。对入江水道行洪能力的分析为淮河下游区的防汛抗洪和降低特大洪水威胁提供借鉴和参考,对区域经济社会又好又快发展具有现实意义。     

老矿山残矿资源回收方案设计中三维探测及建模技术的应用

目前我国绝大多数中小型老矿山残矿回收面临一系列问题，包括资料缺失无法准确判定老采空区及剩余资源位置，无法准确掌握剩余资源形态及可回收量，回收方案设计与实际资源相差较大等。通过将三维探测及建模技术应用于老矿山残矿资源精准定位及回收方案设计中，有助于解决以上问题。以福建浦城屏峰硫铅锌矿为例，通过对老采空区采用三维激光扫描构建采空区三维模型，结合三维建模计算，构建了目前可回收的剩余资源三维模型。通过模型划分及切割，按照矿体实际形态，在三维模型中布设采切及穿孔工程，并将其导入平面施工图中，不仅可以减少设计工作量，而且能够精准匹配矿体，减少设计偏差。由于周边存在大量老采空区，为保障安全，在采空区及剩余资源精准三维模型的基础上，制定了采空区稳定性监测方案，布设了监测传感器，保障了资源回收安全。     

A Topical Formulation of Melatoninergic Compounds Exerts Strong Hypotensive and Neuroprotective Effects in a Rat Model of Hypertensive Glaucoma

Melatonin is of great importance for regulating several eye processes, including pressure homeostasis. Melatonin in combination with agomelatine has been recently reported to reduce intraocular pressure (IOP) with higher efficacy than each compound alone. Here, we used the methylcellulose (MCE) rat model of hypertensive glaucoma, an optic neuropathy characterized by the apoptotic death of retinal ganglion cells (RGCs), to evaluate the hypotensive and neuroprotective efficacy of an eye drop nanomicellar formulation containing melatonin/agomelatine. Eye tissue distribution of melatonin/agomelatine in healthy rats was evaluated by HPLC/MS/MS. In the MCE model, we assessed by tonometry the hypotensive efficacy of melatonin/agomelatine. Neuroprotection was revealed by electroretinography; by levels of inflammatory and apoptotic markers; and by RGC density. The effects of melatonin/agomelatine were compared with those of timolol (a beta blocker with prevalent hypotensive activity) or brimonidine (an alpha 2 adrenergic agonist with potential neuroprotective efficacy), two drugs commonly used to treat glaucoma. Both melatonin and agomelatine penetrate the posterior segment of the eye. In the MCE model, IOP elevation was drastically reduced by melatonin/agomelatine with higher efficacy than that of timolol or brimonidine. Concomitantly, gliosis-related inflammation and the Bax-associated apoptosis were partially prevented, thus leading to RGC survival and recovered retinal dysfunction. We suggest that topical melatoninergic compounds might be beneficial for ocular health.